ISSN 1662-4009 (online)

ey0017.13-11 | Endocrinology | ESPEYB17

13.11. Worldwide secular trends in age at pubertal onset assessed by breast development among girls: a systematic review and meta-analysis

C Eckert-Lind , AS Busch , JH Petersen , FM Biro , G Butler , EV Brauner , A Juul

To read the full abstract: JAMA Pediatr. 2020;174(4):e195881. doi: 10.1001/jamapediatrics.2019.5881• The authors evaluated the change in pubertal onset in healthy girls around the world based on age at thelarche.• Overall, the age at thelarche decreased 0.24 years per decade from 1977 to 2013.• This decrease seems to reflect a worldwide trend....

ey0016.6-7 | Laboratory Medicine in DSD | ESPEYB16

6.7. Sex differences in reproductive hormones during mini-puberty in infants with normal and disordered sex development

TH Johannsen , KM Main , ML Ljubicic , TK Jensen , HR Andersen , MS Andersen , JH Petersen , AM Andersson , A Juul

J Clin Endocrinol Metab. 2018 Aug 1;103(8):3028–3037.doi: 10.1210/jc.2018-00482. PubMed ID: 29917083Minipuberty is a poorly understood developmental event at 1–6 months of age, during which the hypothalamic-pituitary-gonadal axis is transiently activated.This study assessed serum reproductive hormone concentrations in 1840 healthy boys ...

ey0020.2-5 | Important for Clinical Practice | ESPEYB20

2.5. Tracking and cumulative lifetime exposure to IGF-I in 6459 healthy individuals and in SGA children treated with GH

ASL Kjaer , RB Jensen , JH Petersen , A Linneberg , LL Karhus , LS Henriksen , TH Johannsen , KM Main , AR Hoffman , A Juul

Brief summary: The objective of this study was to examine whether IGF-I and IGF-binding protein-3 (IGFBP-3) levels track through childhood into adulthood and to estimate the cumulative lifetime exposure to IGF-I in healthy individuals and in individuals with a defined period of increased IGF-I levels because of GH therapy.Measurement of serum IGF-I is a cornerstone in rhGH treatment monitoring. Keeping serum IGF-I concentrations within the normal referen...

ey0017.7-2 | Clinical Guidance | ESPEYB17

7.2. Sex-specific estrogen levels and reference intervals from infancy to late adulthood determined by LC-MS/MS

H Frederiksen , TH Johannsen , SE Andersen , J Albrethsen , SK Landersoe , JH Petersen , AN Andersen , ET Vestergaard , ME Schorring , A Linneberg , KM Main , AM Andersson , A Juul

To read the full abstract: Journal of clinical endocrinology and metabolism vol. 105,3 (2020):754–768. doi: https://academic.oup.com/jcem/article/105/3/754/5624050The authors used state-of-the-art liquid chromatography tandem mass spectrometry to establish sex-specific reference ranges for estrone (E1) and estradiol (E2) throughout life and evaluate sex-differences.</...

ey0020.2-3 | Important for Clinical Practice | ESPEYB20

2.3. Timing of puberty, pubertal growth, and adult height in short children born small for gestational age treated with growth hormone

EN Upners , LL Raket , JH Petersen , A Thankamony , E Roche , G Shaikh , J Kirk , H Hoey , SA Ivarsson , O Soder , A Juul , RB Jensen

Brief summary: In this study the authors reported the adult height and timing of puberty of a cohort of Danish children born small for gestational age (SGA) and treated with rhGH in comparison with national growth standards. rhGH treatment significantly increased height SDS in adulthood as compared to the height SDS at treatment start. Age at peak height velocity did not differ compared with the reference cohort, although peak height velocity was reduced in SGA subjects. SGA b...